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Actions of Two Dopamine Derivatives at Adreno- And Cholinoceptors

Actions of Two Dopamine Derivatives at Adreno- And Cholinoceptors

I W Rodger, A S Hersom, R D Waigh

J Med Chem. 1979 Jan;22(1):117-9.

PMID: 423175

Abstract:

Salsolinol (1)and 6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrobromide (2) were synthesized and their effects at adreno- and cholinoceptors investigated both in vivo and in vitro. Both 1 and 2 produced agonist effects at cholinoceptors and alpha- and beta-adrenoceptors. Neuromuscular blocking actions were evident in vitro. Compound 2 exhibited anticholinesterase properties both in vivo and in vitro. These results indicate that dopamine derivatives of this type exhibit not only sympathomimetic activity but also complex actions at cholinoceptors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP59709578	Salsolinol hydrobromide		59709-57-8	Price

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