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[Active Constituents From Aloe Arborescens as BACE Inhibitors]

[Active Constituents From Aloe Arborescens as BACE Inhibitors]

Bo Gao, Chun-Suo Yao, Jin-Yun Zhou, Ruo-Yun Chen, Wei-Shuo Fang

Yao Xue Xue Bao. 2006 Oct;41(10):1000-3.

PMID: 17184120

Abstract:

Aim:
To seek for new components as BACE inhibitors from Aloe arborescens.
Methods:
The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.
Results:
Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.
Conclusion:
Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP38412463	Aloenin A		38412-46-3	Price

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