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Activity-based Profiling for Drug Discovery

Remigiusz Serwa, Edward W Tate

Chem Biol. 2011 Apr 22;18(4):407-9.

PMID: 21513874

Abstract:

Activity-based protein profiling (ABPP) is emerging as a game-changing tool for drug discovery, target validation, and basic biology. In this issue, Chang et al. (2011) report the ABPP-facilitated discovery of JW480, a highly selective potent and orally bioavailable inhibitor of monoalkylglycerol ether hydrolase KIAA1363 that dramatically impairs in vivo growth of human prostate cancer cell lines.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1354359537 JW480 JW480 1354359-53-7 Price
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