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Activity of Hypertonic Solution With Silver and Potassium Sucrose Octasulfate on Nasal Symptoms in Obstructive Rhinopathy With and Without Rhinosinusitis

Activity of Hypertonic Solution With Silver and Potassium Sucrose Octasulfate on Nasal Symptoms in Obstructive Rhinopathy With and Without Rhinosinusitis

Desiderio Passali, Jacopo Cambi, Francesco Maria Passali, Luisa Bellussi

Springerplus. 2013 Dec 13;2:668.

PMID: 24683527

Abstract:

Background:
Nasal obstruction is a primary symptom of common upper respiratory tract disorders. In clinical practice nasal saline solutions are recommended for the cleansing of nasal cavities and relieving nasal symptoms.
Methods:
55 patients (aged 25-70 years) suffering from obstructive rhinopathy, with nasal obstruction/congestion of moderate severity persistent since at least 10 days in advance of recruitment with/without rhinosinusitis was randomly treated with an hypertonic solution composed by Silver Sucrose Octasulfate and Potassium Sucrose Octasulfate (SILSOS) or isotonic solution for 20 days. At baseline (T0), ten days (T10) and twenty days (T20) after SILSOS treatment, study participants were evaluated subjectively with VAS and SNOT-22, objectively by Active Anterior Rhinomanometry (AAR) and MCC/MCTt determination. Forty-four patients were followed-up 30 days after the end of treatment by a phone interview.
Results:
The AAR analysis showed in SILSOS group a significantly (p < 0.05) ameliorated in expiratory flow, at T0-T10 and T0-T20. No improvement in MCTt was observed over the 20 days study period. The mean values MCC of significantly improved at T20 (p < 0.05). VAS total score showed improvement along all time-intervals. Nasal obstruction was back 30 days after the end of treatment with SILSOS in only 3 patients and reported to be in a mild form.
Conclusions:
The obtained results show that SILSOS hyper has added to the mechanical action of removal of secretions a specific decongestant and antiseptic effect lasting longer after the end of treatment. Could help to fluidize thick mucus, improve respiration and promote resolution of symptoms, preventing pathogens adhesion to nasal mucosa.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP76578819	Potassium sucrose octasulfate		76578-81-9	Price

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