Home
Resources
Publications
Acute Amino Acids Supplementation Enhances Pituitary Responsiveness in Athletes

Acute Amino Acids Supplementation Enhances Pituitary Responsiveness in Athletes

L di Luigi, L Guidetti, F Pigozzi, C Baldari, A Casini, M Nordio, F Romanelli

Med Sci Sports Exerc. 1999 Dec;31(12):1748-54.

PMID: 10613424

Abstract:

Purpose:
The purpose of this study was to determine the effect of a mixture of amino acids on pituitary responsiveness to a stimulation test (GnRH + CRH) in athletes.
Methods:
In a double blinded counterbalanced experimental protocol, 10 moderately trained male athletes performed the pituitary stimulation test 60 min after a single oral administration of a placebo (P1-AS) or an amino acid mixture solution (AS) (L-arginine hydrochloride 100 mg x kg(-1) + L-ornithine hydrochloride 80 mg x kg(-1) + L-branched chain amino acids 140 mg x kg(-1): 50% L-leucine, 25% L-isoleucine, 25% L-valine) on two different occasions. Plasma ACTH, LH, FSH, GH, and cortisol were evaluated before (-60, -30, 0 min) and after (+15, +30, +45, +60, +90 min) the stimulation test.
Results:
The ACTH, LH and FSH response to CRH + GnRH was significantly higher in AS group both as absolute values and area under curve (AUC) values than in P1-AS group. Pre-test and post-test cortisol AUC levels were significantly higher in P1-AS group although a higher percent increase in post-test cortisol was found in AS group. The total GH-AUC was higher in AS group and, as expected, the absolute GH concentrations at different time points were not influenced by CRH + GnRH administration.
Conclusion:
The amino acid mixture used enhanced the ACTH, LH, and FSH response to CRH + GnRH.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17694983	L-Isoleucine hydrochloride solution		17694-98-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: