0

Acute Generalized Exanthematous Pustulosis Induced by Paracetamol. A Case With Severe Hemodynamic Disturbances

A L De Coninck, A S Van Strubarq, M A Pipeleers-Marichal, L P Huyghens, E T Suys, D I Roseeuw

Dermatology. 1996;193(4):338-41.

PMID: 8993963

Abstract:

We report on a 28-year-old Bangladesh man with acute generalized exanthematous pustulosis, induced by paracetamol. The patient presented with an erythematous and pustular eruption after taking 1 tablet of paracetamol for a sore throat. After intravenous administration of propacetamol hydrochloride (which is a prodrug of paracetamol), the rash became worse, showing a toxic epidermal necrolysis-like appearance and the patient suffered from severe hemodynamic disturbances. After discontinuation of propacetamol hydrochloride, the eruption cleared within 2 days. Prick testing performed in the patient revealed a positive reaction for propacetamol hydrochloride.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP66532863 Propacetamol hydrochloride Propacetamol hydrochloride 66532-86-3 Price
qrcode