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Acute Toxicity, Antiedematogenic Activity, and Chemical Constituents of Palicourea Rigida Kunth

Acute Toxicity, Antiedematogenic Activity, and Chemical Constituents of Palicourea Rigida Kunth

Vanessa G Alves, Elisa A da Rosa, Laura L M de Arruda, Bruno A Rocha, Ciomar A Bersani Amado, Silvana M O Santin, Armando M Pomini, Cleuza C da Silva

Z Naturforsch C J Biosci. 2016 Mar;71(3-4):39-43.

PMID: 26927220

Abstract:

The phytochemical study of the leaves, roots, and flowers of Palicourea rigida led to the isolation of the triterpenes betulinic acid (1) and lupeol (2), the diterpene phytol (3), and the iridoid glycosides sweroside (4) and secoxyloganin (5). These compounds were identified using NMR 1H and 13C and comparing the spectra with published data. We studied the antiedematogenic activity of crude extracts from the organs, and of different fractions, in mice and found that the n-hexane fraction of the leaf extract significantly inhibited the ear edema resulting from croton oil administration. The crude extract from leaves was not acutely toxic to the mice.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP58822472	Secoxyloganin		58822-47-2	Price

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