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Acyclic Neutral Carrier-Based Polymer Membrane Electrode for a Stimulant, Phentermine

Acyclic Neutral Carrier-Based Polymer Membrane Electrode for a Stimulant, Phentermine

T Katsu, K Ido, K Kataoka

Anal Sci. 2001 Jun;17(6):745-9.

PMID: 11707945

Abstract:

Groups of dioxadicarboxylic diamides, which were developed as potential ionophores for inorganic cations, were found to act as ionophores for a stimulant, phentermine. Especially, N,N-dioctadecyl-N',N'-dipropyl-3,6-dioxaoctanediamide, which was originally developed as a lead ionophore and is commercially available from Fluka as lead ionophore I, was suitable for making a phentermine-selective electrode. The electrode constructed using this ionophore and bis(2-ethylhexyl) sebacate as a solvent mediator in a poly(vinyl chloride) membrane matrix discriminated between phentermine and analogous compounds more effectively than an electrode based on dibenzo-18-crown-6, a representative ionophore for organic ammonium ions. Moreover, the present electrode showed remarkably little interference by inorganic cations, such as Na+ and K+, as well as lipophilic quaternary ammonium ions including (C2H5)4N+ and (C3H7)4N+. The electrode exhibited a near-Nernstian response to phentermine in the concentration range of 2 x 10(-6) to 1 x 10(-2) M with a slope of 54.8 mV per concentration decade in 0.1 M MgCl2. The lower limit of detection was 7 x 10(-7) M. This electrode was applied to determine phentermine in a cationic-exchange resin complex of this stimulant, which is the general dosage form in medical use.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP32195554-A	Chloride ionophore I		32195-55-4	Price
AP6833847	Ammonium ionophore I		6833-84-7	Price

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