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Addressing the Malaria Drug Resistance Challenge Using Flow Cytometry to Discover New Antimalarials

Brian T Grimberg, Maria M Jaworska, Lindsay B Hough, Peter A Zimmerman, James G Phillips

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5452-7.

PMID: 19666223

Abstract:

A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 microM) overall and ring stage in vitro antimalarial activity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP658084232-B SU 11274 SU 11274 658084-23-2 Price
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