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Addressing the Stability of C-capped Dipeptide Efflux Pump Inhibitors That Potentiate the Activity of Levofloxacin in Pseudomonas Aeruginosa

T E Renau, R Léger, E M Flamme, M W She, C L Gannon, K M Mathias, O Lomovskaya, S Chamberland, V J Lee, T Ohta, K Nakayama, Y Ishida

Bioorg Med Chem Lett. 2001 Mar 12;11(5):663-7.

PMID: 11266165

Abstract:

Synthetic optimization of a biologically labile class of dipeptides that function as efflux pump inhibitors to potentiate the antibacterial agent levofloxacin in Pseudomonas aeruginosa has led to the discovery of a related series of compounds that are completely stable in a variety of biological matrices. Other than the stability profile, the in vitro profile of the new series is essentially identical to that observed with the original one. A prototypical compound from the new series demonstrates potentiation in an in vivo model of infection.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP177472309 Levofloxacin Related Compound C Levofloxacin Related Compound C 177472-30-9 Price
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