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Adiponectin Inhibits lymphotoxin-β Receptor-Mediated NF-κB Signaling in Human Umbilical Vein Endothelial Cells

Adiponectin Inhibits lymphotoxin-β Receptor-Mediated NF-κB Signaling in Human Umbilical Vein Endothelial Cells

Yizhou Xu, Chu Zhang, Ningfu Wang, Feng Ling, Peizhang Li, Yan Gao, Wei Hua

Biochem Biophys Res Commun. 2011 Jan 28;404(4):1060-4.

PMID: 21195057

Abstract:

Adiponectin exerts anti-diabetic and anti-atherogenesis properties through its 2 receptors (AdipoR1 and AdipoR2). However, the signaling pathways responsible for the anti-inflammatory effects of adiponectin are largely unknown. In this study, we identified the lymphotoxin (LT)-β receptor (LTBR) as an interacting partner of human AdipoR1 by using a yeast two-hybrid screening. The interaction between LTBR and AdipoR1 was confirmed by co-immunoprecipitation and co-localization analysis. Furthermore, adiponectin incubation inhibited lymphotoxin-induced NF-κB activation and the expression of adhesion molecules in human umbilical vein endothelial cells. These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-κB pathway.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413760	Lymphotoxin-α1/β2 human			Price

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