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Adjunctive Use of an Ethyl Lauroyl arginate-(LAE-)-containing Mouthwash in the Nonsurgical Therapy of Periodontitis: A Randomized Clinical Trial

Adjunctive Use of an Ethyl Lauroyl arginate-(LAE-)-containing Mouthwash in the Nonsurgical Therapy of Periodontitis: A Randomized Clinical Trial

Andrea Pilloni, Mauro Carere, Germano Orrù, Alessandra Scano, Cinzia Trezza, Mariana A Rojas, Blerina Zeza

Minerva Stomatol. 2018 Feb;67(1):1-11.

PMID: 29087093

Abstract:

Background:
This randomized clinical trial evaluated the clinical and microbiological effects of 0.147% ethyl lauroyl arginate (LAE)-containing mouthwash compared to 0.12% chlorhexidine (CHX) mouthwash in the treatment of periodontitis.
Methods:
Subjects were randomized to use 0.147% LAE and 0.12% CHX mouthwash after professional mechanical plaque removal (PMPR) twice daily 1 hour after brushing for 4 weeks. Periodontal pocket depth (PPD), bleeding on probing (FMBS) and dental plaque (FMPS) were measured at baseline, 4 weeks and 3 months. Microbiological samples were taken at baseline, at 4 weeks and 3 months after plaque recording and prior to PPD and BoP measurements.
Results:
Forty subjects were randomized to treatment. Both therapies resulted in reduced FMPS, FMBS and residual pockets at 4 weeks and 3 months. The differences were not statistically significant. There were no treatment-related adverse events. Total bacterial count and the specific pathogens were reduced at 4 weeks and 3 months by both mouthwashes with no statistical differences between them at neither period of time.
Conclusions:
A mouthwash containing 0.147% LAE could be an alternative to the use of 0.12% CHX in the non-surgical therapy of periodontitis considering the similar clinical effects, more stable microbiological improvement and absence of adverse effects.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP60372772	Ethyl lauroyl arginate		60372-77-2	Price

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