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Adsorption of Heterologous Gamma-Globulins by Chopped Guinea-Pig Lung

C A King, G E Francis

Immunology. 1967 Jul;13(1):1-8.

PMID: 4165631

Abstract:

The amounts of firmly bound γ-globulin (i.e. resistant to elution by Tyrode's solution) showed marked differences when the absorption of various heterologous γ-globulins on chopped guinea-pig lung was compared [Sheep>pig>bovine>horse>human>rabbit]. This suggests that non-sensitizing γ-globulins were more readily adsorbed than the sensitizing γ-globulins.
Only about 30-40 per cent of 131I-labelled protein could be removed from the firmly bound γ-globulin-tissue complex using 8 M urea, suggesting that covalent bonds play a major role in the fixation of γglobulins to tissues.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP9007834-D γ-Globulins from sheep γ-Globulins from sheep 9007-83-4 Price
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