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Advances in Fmoc Solid-Phase Peptide Synthesis

Advances in Fmoc Solid-Phase Peptide Synthesis

Raymond Behrendt, Peter White, John Offer

J Pept Sci. 2016 Jan;22(1):4-27.

PMID: 26785684

Abstract:

Today, Fmoc SPPS is the method of choice for peptide synthesis. Very-high-quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS. Many modified derivatives are commercially available as Fmoc building blocks, making synthetic access to a broad range of peptide derivatives straightforward. The number of synthetic peptides entering clinical trials has grown continuously over the last decade, and recent advances in the Fmoc SPPS technology are a response to the growing demand from medicinal chemistry and pharmacology. Improvements are being continually reported for peptide quality, synthesis time and novel synthetic targets. Topical peptide research has contributed to a continuous improvement and expansion of Fmoc SPPS applications.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS741141	FMOC NH2-PEG3500-NH2TFA			Price

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