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Advances in Peptide-based DNA/RNA-Intercalators

Advances in Peptide-based DNA/RNA-Intercalators

Josipa Matić, Lidija-Marija Tumir, Marijana Radić Stojković, Ivo Piantanida

Curr Protein Pept Sci. 2016;17(2):127-34.

PMID: 26521958

Abstract:

Interactions between DNA/RNA and huge variety of peptides are quite common in nature, controlling vast number of processes. Also, there are several naturally occurring small molecules which contain peptide and DNA intercalator in structure, whereby their biological activity is based on synergistic interactions of both components; for instance bis-intercalator echinomycin. Versatility of synthetic approaches to short peptides allowed their usage as simple recognition units within the DNA or RNA grooves or as backbone carriers for variety of bioactive substituents attached to amino acid side chains, one of very popular examples being PNAs. Such peptide-backbones were also used for synthesis of novel intercalators and poly-intercalators, many of them showing intriguing novel DNA/RNA interacting properties.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP512641	Echinomycin		512-64-1	Price

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