0

Age-dependent Suppression of Hippocampal Epileptic Afterdischarges by Metabotropic Glutamate Receptor 5 Antagonist MTEP

Cecilia Zavala-Tecuapetla, Hana Kubová, Jakub Otáhal, Grygoriy Tsenov, Pavel Mareš

Pharmacol Rep. 2014 Oct;66(5):927-30.

PMID: 25150003

Abstract:

Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP329205687 mGluR5 Antagonist, MTEP - CAS 329205-68-7 mGluR5 Antagonist, MTEP - CAS 329205-68-7 329205-68-7 Price
qrcode