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Albumin-induced Changes of Fluorescence Spectra of 1-pyrenebutyric Acid

Albumin-induced Changes of Fluorescence Spectra of 1-pyrenebutyric Acid

Y Matsushita, M Tsukiori, T Suzuki, I Moriguchi

J Pharm Sci. 1986 Feb;75(2):193-4.

PMID: 3958932

Abstract:

Changes in the fluorescence spectra and quantum yield of 1-pyrenebutyric acid (1) induced by human, bovine, rabbit, and dog serum albumins and healthy adult serum, liver-disease patient serum, and renal-disease patient serum were compared at pH 7.4. Human serum albumin, healthy adult serum, and liver-disease patient serum caused marked quenching of the fluorescence of 1-pyrenebutyric acid. On the contrary, bovine, rabbit, and dog serum albumins increased the fluorescence intensity. Renal-disease patient serum also enhanced the intensity but caused quenching of the fluorescence after treatment with charcoal. Thus, 1-pyrenebutyric acid clearly shows interspecies differences in the environment or the structure of the binding site on serum albumin between humans and other animals. Furthermore, it is suggested that some substance which influences the character of the binding site for 1-pyrenebutyric acid exists in the serum of renal-disease patients.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3443456	1-Pyrenebutyric acid		3443-45-6	Price

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