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Alcohol and Hypertension-New Insights and Lingering Controversies

Alcohol and Hypertension-New Insights and Lingering Controversies

Ian B Puddey, Trevor A Mori, Anne E Barden, Lawrence J Beilin

Curr Hypertens Rep. 2019 Sep 7;21(10):79.

PMID: 31494743

Abstract:

Purpose of review:
To examine outstanding issues in the relationship of alcohol to hypertension. These include whether the increase in BP with alcohol is causally related, the nature of the relationship in women, the contribution of alcohol-related increases in BP to cardiovascular disease and the aetiology of alcohol-related hypertension.
Recent findings:
Intervention studies and Mendelian randomisation analyses confirm the alcohol-BP relationship is causal. The concept that low-level alcohol intake reduces BP in women is increasingly unsustainable. Alcohol-related hypertension is in the causal pathway between alcohol use and increased risk for several cardiovascular outcomes. The aetiology of alcohol-related hypertension is multifactorial with recent data highlighting the effects of alcohol on the vasoconstrictor 20-HETE and oxidative stress. The high prevalence of both alcohol use and hypertension mandates a careful alcohol history in every patient with elevated BP. Early intervention for excessive alcohol use offers the promise of lower levels of BP and reduced risk of adverse cardiovascular outcomes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2726730	12-Hydroxystearyl alcohol		2726-73-0	Price

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