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[Aliskiren Hemifumarate]

[Aliskiren Hemifumarate]

K Kappert, T Unger, U Kintscher

Dtsch Med Wochenschr. 2008 Jun;133(24):1308-12.

PMID: 18465684

Abstract:

Aliskiren, a renin inhibitor, is the first in a new class of drugs interfering with the renin angiotensin system. Aliskiren was approved by the US Food and Drug Administration (FDA) in March 2007, and in Europe in August 2007 for the treatment of hypertension (marketed as Tekturna and Rasilez, respectively). Several clinical trials demonstrated effective blood pressure reduction due to aliskiren treatment. Whether aliskiren exhibits morbidity and mortality benefits for patients beyond its blood pressure reduction capability, can only be judged after realization of comparative long-term clinical trials. Furthermore, it remains to be seen, whether the use of aliskiren will be indicated for treatment of additional diseases, as it was the case for other inhibitors of the renin angiotensin system. In fact, recent and ongoing clinical trials regarding heart failure and diabetic nephropathy demonstrated first beneficial effects of aliskiren in these conditions (reduction of urinary albumin/creatinine-ratio and NTproBNP, respectively).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP173334582	Aliskiren hemifumarate		173334-58-2	Price

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