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Alkylative Preparation of α-Silylalkylmagnesium from R 3 SiCHBr 2 Using a Magnesate Reagent

Junichi Kondo, Atsushi Inoue, Hiroshi Shinokubo, Koichiro Oshima

Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2085-2087.

PMID: 29712205

Abstract:

Magnesium-bromine exchange to provide the 1-bromo-1-silylmethylmagnesium species is mediated by treatment of dibromomethylsilane with an trialkylmagnesate reagent. The addition of a copper catalyst induces facile migration of an alkyl group to afford an α-silylalkylmagnesium compound, which furnishes α-silyl ketones in good yield upon treatment with acyl chloride.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP20910207 Tri-n-butyllithium magnesate Tri-n-butyllithium magnesate 20910-20-7 Price
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