Home
Resources
Publications
Allergic Response to Glucagon Injection as a Result of Insulin Contamination

Allergic Response to Glucagon Injection as a Result of Insulin Contamination

A E Kitabchi, N Lamkin Jr, P Lieberman, V Ayyagari, F K Baskin

J Clin Endocrinol Metab. 1975 Nov;41(5):863-7.

PMID: 1184721

Abstract:

A 25-year-old obese woman with adult onset diabetes, with known insulin allergy, was evaluated for her insulin response to glucagon. Intravenous injection of glucagon produced severe generlaized allergic reaction. Skin tests with various insulin and glucagon preparations showed allergic reaction to be most pronounced with beef regular single peak and single component insulin, pork regular single peak, beef lente single peak, and neutral regular (beef-pork) single peak insulin. Allergic reactions to numerous glucagon preparations were found to be directly proportional to the amount of insulin contamination in those preparations. Purification of one glucagon lot by column chromatography verified the presence of proinsulin and insulin contaminants in the preparation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12584586	Insulin (Pork)		12584-58-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: