Home
Resources
Publications
Alpha-boswellic Acid Protects Against Ethanol-Induced Gastric Injury in Rats: Involvement of Nuclear Factor erythroid-2-related Factor 2/heme oxygenase-1 Pathway

Alpha-boswellic Acid Protects Against Ethanol-Induced Gastric Injury in Rats: Involvement of Nuclear Factor erythroid-2-related Factor 2/heme oxygenase-1 Pathway

Yikai Zhang, Jing Jia, Yi Ding, Yongzheng Ma, Peijin Shang, Tianlong Liu, Guangfei Hui, Lin Wang, Mingming Wang, Zhihui Zhu, Yuwen Li, Aidong Wen

J Pharm Pharmacol. 2016 Apr;68(4):514-22.

PMID: 26992040

Abstract:

Objectives:
The purpose of this study was to assess the gastroprotective properties of alpha-boswellic acid (α-BA), a pentacyclic triterpene compound from extracts of Frankincense.
Methods:
The gastroprotection of α-BA was assessed with ethanol-induced gastric lesions model, by histopathological assessment and measuring gastric juice acidity (pH), gastric wall mucus (GWM), prostaglandins E2 (PGE-2), membrane lipids peroxidation (MDA), superoxide dismutase (SOD) activity, catalase (CAT) activity and amount of nitric oxide (NO). The gastroprotective effects of α-BA through the nuclear factor erythroid-2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) anti-oxidative pathway were presented and measured by immunohistochemistry and Western blot.
Key findings:
The results showed that α-BA reduced injuries associated with the administration of ethanol, gastric juice acidity and the formation of MDA and increased CAT activity and SOD activity and the level of NO and PGE-2 in a dose-depended manner. The expression of both Nrf2 and HO-1 was significantly increased in the group treated with 200 mg/kg α-BA, which suggested that activation of the Nrf2/HO-1 pathway might be critical in α-BA's prevention of gastric ulcers.
Conclusions:
These findings demonstrate that α-BA decreases oxidative stress and that the Nrf2/HO-1 pathway might play a role in the gastroprotective action of α-BA in ethanol-induced gastric injury in rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP471669	α-Boswellic acid		471-66-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: