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Alpha-lipoic Acid Treatment of 31 Patients With Sore, Burning Mouth

Alpha-lipoic Acid Treatment of 31 Patients With Sore, Burning Mouth

J C Steele, A J Bruce, L A Drage, R S Rogers 3rd

Oral Dis. 2008 Sep;14(6):529-32.

PMID: 18266840

Abstract:

Objective:
To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms.
Design:
Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients was a prescription/recommendation for alpha-lipoic acid. Of these patients, 35 were available for follow-up.
Setting:
Tertiary care academic medical center.
Subjects:
Ambulatory patients given prescription /recommendation for alpha-lipoic acid 600 mg per day, in divided doses.
Main outcome measure:
Reported improvement in symptoms documented in medical records and at follow-up (visits or telephone interviews).
Results:
Thirty-one of the 35 patients (66% of all 47) actually took alpha-lipoic acid as recommended. No patient reported a complete alleviation of symptoms. Six (19%) of these 31 patients felt mostly better, five (16%) felt somewhat better, and 14 (45%) reported no difference. Two patients (7%) reported a worsening of symptoms and four (13%) did not know whether there had been improvement.
Conclusion:
Eleven of 31 patients (35%) reported benefit from taking alpha-lipoic acid. Because we examined only a small number of patients and relied on a subjective outcome assessment, further larger studies using a prospective, randomized, controlled, and double-blind structure are warranted.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1077287-A	Alpha Lipoic Acid		1077-28-7	Price

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