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Alpha-onocerin: An Acetylcholinesterase Inhibitor From Lycopodium Clavatum

Ilkay Orhan, Salih Terzioglu, Bilge Sener

Planta Med. 2003 Mar;69(3):265-7.

PMID: 12677532

Abstract:

In order to find new acetylcholinesterase inhibitors from natural sources which have therapeutic potential in the treatment of Alzheimer's disease, the chloroform : methanol (1 : 1) extracts of five Lycopodium species ( L. clavatum L., L. selago L., L. annotinum L., L. alpinum L., and L. complanatum ssp. chamaecyparissus A. (Br.) Döll.), growing in Turkey (Lycopodiaceae), were screened in vitro by the Ellman spectrophotometric method at 1 mg/ml concentration. Among these extracts, only the extract of L. clavatum was found to be active (49.85 %). Bioassay-guided fractionation of the chloroform extract of L. clavatum led to the isolation of alpha-onocerin (IC 50 = 5.2 microM), a well-known triterpenoid, as the responsible compound for the activity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP511013 Alpha-onocerin Alpha-onocerin 511-01-3 Price
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