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Alpha-pompilidotoxin (alpha-PMTX), a Novel Neurotoxin From the Venom of a Solitary Wasp, Facilitates Transmission in the Crustacean Neuromuscular Synapse

Alpha-pompilidotoxin (alpha-PMTX), a Novel Neurotoxin From the Venom of a Solitary Wasp, Facilitates Transmission in the Crustacean Neuromuscular Synapse

K Konno, A Miwa, H Takayama, M Hisada, Y Itagaki, H Naoki, T Yasuhara, N Kawai

Neurosci Lett. 1997 Dec 5;238(3):99-102.

PMID: 9464629

Abstract:

A new neurotoxin, named alpha-pompilidotoxin (alpha-PMTX) has been found in the venom of the solitary wasp Anoplius safnariensis. In the neuromuscular synapse of the lobster walking leg preparation, alpha-PMTX (10-100 micro/M) caused great enhancement of both the excitatory and inhibitory postsynaptic potentials. Recordings of the excitatory post synaptic currents (EPSCs) at the synaptic sites showed that alpha-PMTX reversibly and dose-dependently potentiates EPSCs. Alpha-PMTX may act primarily on the presynaptic membrane but the mode of action of the toxin is clearly different from other known facilitatory neurotoxins, such as alpha-latrotoxin, apamin or charybdotoxin. This novel toxin will serve as a useful tool in the research field of neuroscience.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4244494	α-Pompilidotoxin			Price

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