Home
Resources
Publications
Alpha-tocopherol Derivatives and Wound Healing in an Experimental Model of Filtering Surgery

Alpha-tocopherol Derivatives and Wound Healing in an Experimental Model of Filtering Surgery

J M Larrosa, V Polo, T Ramirez, I Pinilla, L E Pablo, F M Honrubia

Ophthalmic Surg Lasers. Mar-Apr 2000;31(2):131-5.

PMID: 10743924

Abstract:

Objective:
To describe the effect of alpha-tocopherol derivatives (acetate and acid-succinate) on the histopathological characteristics of the surgical fistula in an experimental model of filtering surgery.
Materials and methods:
Thirty pigmented rabbits were divided into 3 groups. Twenty-four hours before surgery the animals were injected subconjunctivally with 0.5 mL of solution that depended on the group of treatment: Group 1 (n = 10) 0.75% ethanol in balanced salt solution (BSS); Group 2 (n = 10) 100 microg alph-tocopherol-acetate in 0.75% ethanol in BSS; Group 3 (n = 10) 100 microg alpha-tocopheryl-acid-succinate in 0.75% ethanol in BSS. Histological findings were evaluated 30 days after surgery.
Results:
The groups treated with alpha-tocopherol derivatives showed a higher percentage of persistence of the fistula and better intraocular pressure (IOP) control.
Conclusions:
Alpha-tocopherol derivatives showed antiproliferative properties in this experimental model of filtering surgery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4345033-A	Alpha tocopheryl acid succinate		4345-03-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: