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Alternariol 9-methyl Ether From the Endophytic Fungus Alternaria Sp. Samif01 and Its Bioactivities

Alternariol 9-methyl Ether From the Endophytic Fungus Alternaria Sp. Samif01 and Its Bioactivities

Jingfeng Lou, Ruiting Yu, Xiaohan Wang, Ziling Mao, Linyun Fu, Yang Liu, Ligang Zhou

Braz J Microbiol. Jan-Mar 2016;47(1):96-101.

PMID: 26887231

Abstract:

One bioactive compound, identified as alternariol 9-methyl ether, was isolated from the crude extract of the endophytic fungus Alternaria sp. Samif01 residing in the roots of Salvia miltiorrhiza Bunge. Alternariol 9-methyl ether was active against bacteria with minimum inhibitory concentration values ranging from 25 to 75μg/mL and median inhibitory concentration (IC50) values ranging from 16.00 to 38.27μg/mL. The IC50 value of alternariol 9-methyl ether against spore germination of Magnaporthe oryzae was 87.18μg/mL. Alternariol 9-methyl ether also showed antinematodal activity against Bursaphelenchus xylophilus and Caenorhabditis elegans with IC50 values of 98.17μg/mL and 74.62μg/mL, respectively. This work is the first report on alternariol 9-methyl ether and its biological activities from the endophytic fungus Alternaria sp. Samif01 derived from S. miltiorrhiza Bunge. The results indicate the potential of Alternaria sp. Samif01 as a source of alternariol 9-methyl ether and also support that alternariol 9-methyl ether is a natural compound with high potential bioactivity against microorganisms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP641383	Alternariol from Alternaria sp.		641-38-3	Price

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