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Alzheimer's Disease Amyloid Beta Peptide 25-35 Inhibits Lipid Peroxidation as a Result of Its Membrane Interactions

Alzheimer's Disease Amyloid Beta Peptide 25-35 Inhibits Lipid Peroxidation as a Result of Its Membrane Interactions

M F Walter, P E Mason, R P Mason

Biochem Biophys Res Commun. 1997 Apr 28;233(3):760-4.

PMID: 9168929

Abstract:

The biological activity of the Alzheimer's disease amyloid beta protein may be related to modulation of membrane lipid peroxidation. The effect of amyloid beta protein fragment 25-35 [A beta(25-35)] on lipid peroxidation was examined in liposomes enriched with polyunsaturated fatty acids. The activity of A beta(25-35) was compared to that of A beta(25-35) with either a scrambled sequence [A beta(25-35)scram] or a peptide sequence in which methionine was replaced with leucine [A beta(25-35) met]. A beta(25-35) inhibited lipid peroxidation in a dose- and time-dependent manner. The antioxidant activity of A beta(25-35) was observed at concentrations as low as 10 nM. The relative antioxidant activities of the amyloid beta protein fragments were as follows: A beta(25-35) > A beta(25-35) met > A beta(25-35)scram. The two more potent peptides intercalated into the membrane hydrocarbon core, as determined by small-angle x-ray diffraction approaches. These findings indicate that the amphiphilic A beta(25-35) peptide inhibits lipid peroxidation at low concentrations as a result of physicochemical interactions with the membrane lipid bilayer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP131602534	Amyloid β-Protein Fragment 25-35		131602-53-4	Price

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