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Ameliorating Efficacy of Eugenol Against Metanil Yellow Induced Toxicity in Albino Wistar Rats

Ameliorating Efficacy of Eugenol Against Metanil Yellow Induced Toxicity in Albino Wistar Rats

Uma Kant Sharma, Ramesh Kumar, Ashutosh Gupta, Risha Ganguly, Amit Kumar Singh, Anil Kumar Ojha, Abhay Kumar Pandey

Food Chem Toxicol. 2019 Apr;126:34-40.

PMID: 30738991

Abstract:

Metanil yellow, an azo dye, is a non-permitted synthetic food colour used extensively in India and other developing countries as food additive. Present communication reports the toxic effects of metanil yellow on hepatic and kidney tissues and its amelioration by eugenol, vitamin E and vitamin C. Oral administration of metanil yellow in albino Wistar rats for 28 days caused elevation in serum enzymes (glutamate oxaloacetate transaminase, gluatamate pyruvate transaminase, alkaline phosphatase), and total bilirubin along with decline in albumin and total protein levels. At tissue level, activities of oxidative stress markers viz., superoxide dismutase, catalase and reduced glutathione in liver and kidney were reduced to about half while malondialdehyde level increased significantly under the influence of metanil yellow. Co-administration of eugenol/vitamin E/vitamin C in metanil yellow intoxicated rats exhibited considerable restoration of oxidative stress as well as hepatic and renal function markers in serum and tissues. The study revealed that eugenol has antioxidant, hepatoprotective and renoprotective activities.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP587984	Metanil Yellow		587-98-4	Price

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