Home
Resources
Publications
Amide Bond Activation of Biological Molecules

Amide Bond Activation of Biological Molecules

Sriram Mahesh, Kuei-Chien Tang, Monika Raj

Molecules. 2018 Oct 12;23(10):2615.

PMID: 30322008

Abstract:

Amide bonds are the most prevalent structures found in organic molecules and various biomolecules such as peptides, proteins, DNA, and RNA. The unique feature of amide bonds is their ability to form resonating structures, thus, they are highly stable and adopt particular three-dimensional structures, which, in turn, are responsible for their functions. The main focus of this review article is to report the methodologies for the activation of the unactivated amide bonds present in biomolecules, which includes the enzymatic approach, metal complexes, and non-metal based methods. This article also discusses some of the applications of amide bond activation approaches in the sequencing of proteins and the synthesis of peptide acids, esters, amides, and thioesters.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP104809292	Nle-Arg-Phe amide	104809-29-2	Price
AP128340476	Lys-Ala-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle amide	128340-47-6	Price
AP155206001	17-Phenyl-tri-norprostaglandin F2α-ethyl amide	155206-00-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: