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Amino Acid Sequence of Human Liver Cathepsin B

Amino Acid Sequence of Human Liver Cathepsin B

A Ritonja, T Popovic, V Turk, K Wiedenmann, W Machleidt

FEBS Lett. 1985 Feb 11;181(1):169-72.

PMID: 3972105

Abstract:

The complete amino acid sequence of cathepsin B (EC 3.4.22.1) from human liver was determined. The 252-residue sequence was obtained by automated solid-phase Edman degradation of the light and heavy chain resulting from limited proteolysis of the single-chain enzyme and of fragments produced by cyanogen bromide and enzymatic cleavage of the heavy chain. Human liver cathepsin B has 83.7% identical residues with the corresponding enzyme from rat liver. Comparison of both mammalian cathepsin B sequences with the sequence of papain provides further evidence that lysosomal and plant cysteine proteinases have evolved from a common ancestor and share a similar catalytic mechanism.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9047227-B	Cathepsin B, Human Liver		9047-22-7	Price

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