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Amphotericin B Deoxycholate for Relapse Visceral Leishmaniasis in Bangladesh: A Cross-Sectional Study

Amphotericin B Deoxycholate for Relapse Visceral Leishmaniasis in Bangladesh: A Cross-Sectional Study

Md Golam Hasnain, Proggananda Nath, Shomik Maruf, Shah Golam Nabi, A F M Akhtar Hossain, Be-Nazir Ahmed, Dinesh Mondal, Ariful Basher

BMC Res Notes. 2018 Dec 22;11(1):918.

PMID: 30577877

Abstract:

Objective:
Based on studies in India (as there was no studies from outside India) amphotericin B deoxycholate has been considered as a backup drug for treatment of visceral leishmaniasis. However, treatment response and adverse effect to anti-leishmanial drugs may vary across different populations and in Bangladesh the effect to amphotericin B deoxycholate for treatment of visceral leishmaniasis is still unknown. Therefore, there is a need to explore cure rate and adverse effects to amphotericin B deoxycholate to justify its use on visceral leishmaniasis patients in Bangladesh.
Result:
Here we report 34 visceral leishmaniasis patients who received treatment with amphotericin B deoxycholate in the Surya Kanta Kala-azar Research Centre from December 2011 to June 2015. The dose of the treatment was 1 mg/kg body weight for 15 days followed up until 12 months after treatment. Response to amphotericin B deoxycholate treatment was excellent as all 34 patients achieved a final cure. Hypokalaemia (47%), shivering (47%), vomiting (35%) and acidity (15%) were most common adverse events. However, we did not observe any serious adverse events. Amphotericin B deoxycholate for relapse visceral leishmaniasis was found to be highly effective and safe. Our study justified to include amphotericin B deoxycholate as a second line drug for visceral leishmaniasis in Bangladesh.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1397893-A	Amphotericin B		1397-89-3	Price

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