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Amplification of the Bradykinin Response in Rat Uterus by pCMB-Dextran T 10

K Mann, F Bachhuber, H Kather, B Simon

Agents Actions. 1975 Aug;5(3):236-8.

PMID: 1236639

Abstract:

pCMB-Dextran T 10,a large, non-penetrating SH-blocking reagent caused a reversible amplification of bradykinin sensituvity in the isolated rat uterus. High concentrations of this compound (1 x 10-3 M) can evoke spontaneous uterus contraction. pCMB-Dextran T 10 did not alter the biological activity of bradykinin. It is assumed that superficial membrane SH-groups are involved in the uterus contraction mechanism.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP9004540-O Dextran T-10 Dextran T-10 9004-54-0 Price
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