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Amyotrophic Lateral Sclerosis and Parkinsonism in Papua, Indonesia: 2001-2012 Survey Results

Amyotrophic Lateral Sclerosis and Parkinsonism in Papua, Indonesia: 2001-2012 Survey Results

Kiyohito Okumiya, Taizo Wada, Michiko Fujisawa, Masayuki Ishine, Eva Garcia Del Saz, Yutaka Hirata, Shigeki Kuzuhara, Yasumasa Kokubo, Harumichi Seguchi, Ryota Sakamoto, Indrajaya Manuaba, Paulina Watofa, etc.

BMJ Open. 2014 Apr 16;4(4):e004353.

PMID: 24740977

Abstract:

Objective:
Only one previous follow-up study of amyotrophic lateral sclerosis (ALS) and parkinsonism in Papua, Indonesia has been carried out since a survey undertaken in 1962-1981 by Gajdusek and colleagues. Therefore, to clarify the clinical epidemiology of ALS and parkinsonism in the southern coastal region of Papua, the clinical characteristics and prevalence of the diseases in this region were examined and assessed.
Methods:
Cases of ALS and parkinsonism were clinically examined during a 2001-2012 survey in Bade and other villages along the Ia, Edera, Dumut and Obaa rivers in Papua, Indonesia. Possible, probable and definite ALS was diagnosed clinically by certified neurologists based on El Escorial criteria. The criteria for a diagnosis of parkinsonism were the presence of at least two of the four following signs: tremor, rigidity, bradykinesia and postural impairment with a progressive course.
Results:
During the survey, 46 cases of ALS and/or parkinsonism were diagnosed within a population range of 7000 (2001-2002) to 13 900 (2007-2012). The 46 cases consisted of 17 probable-definite cases of ALS, including three with cognitive impairment (CI), 13 cases of overlapping possible, probable or definite ALS and parkinsonism, including five with CI, and 16 cases of parkinsonism, including one with CI. The crude point prevalence rate of pure ALS was estimated to be at least 73 (95% CI 0 to 156) to 133 (27 to 240)/100 000 people and that of overlapping ALS and parkinsonism at least 53 (0 to 126) to 98 (2 to 193)/100 000 in 2007, or 2010 in some regions.
Conclusions:
While the prevalence of ALS in Papua has decreased over the past ∼30-35 years, it remains higher than the global average. There was a high prevalence of overlapping ALS, parkinsonism and CI, which has also been previously reported in Guam and Kii.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP134531423	OBAA		134531-42-3	Price

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