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An Easy Access to 7-methyl-2-naphthalenecarbonitrile

Hiroyuki Koshio, Tsukasa Ishihara, Hiroyoshi Yamada, Fukushi Hirayama, Yuzo Matsumoto, Isao Yanagisawa

Chem Pharm Bull (Tokyo). 2005 Apr;53(4):448-50.

PMID: 15802851

Abstract:

A practical and cost-effective procedure has been developed for the synthesis of 7-methyl-2-naphthalenecarbonitrile, the precursor of the anticoagulant agents YM-60828 or YM-96765. This new route generates the key intermediate in only two steps from readily available 3-cyanopropionaldehyde dimethyl acetal and m-tolualdehyde, without requiring chromatographic purification. The synthesis involves condensation of the cyano derivative with the aldehyde and subsequent cyclodehydration.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1125888 Benzaldehyde dimethyl acetal Benzaldehyde dimethyl acetal 1125-88-8 Price
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