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An Efficient Chemical Synthesis of Nicotinamide Riboside (NAR) and Analogues

Shinji Tanimori, Takeshi Ohta, Mitsunori Kirihata

Bioorg Med Chem Lett. 2002 Apr 22;12(8):1135-7.

PMID: 11934573

Abstract:

A simple and efficient synthesis of nicotinamide riboside (NAR) 1 and derivatives 4 and 5 via trimethylsilyl trifluoromethanesulfonate (TMSOTf)-mediated N-glycosilation followed by spontaneous deacetylation by treating with methanol is reported.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1105675624 5-Methoxy-N-phenyl-4-(trimethylsilyl)nicotinamide 5-Methoxy-N-phenyl-4-(trimethylsilyl)nicotinamide 1105675-62-4 Price
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