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An Enantio- And Stereocontrolled Synthesis of (-)-Mycestericin E via Cinchona Alkaloid-Catalyzed Asymmetric Baylis-Hillman Reaction

Y Iwabuchi, M Furukawa, T Esumi, S Hatakeyama

Chem Commun (Camb). 2001 Oct 7;(19):2030-1.

PMID: 12240274

Abstract:

A new enantiocontrolled synthesis of a potent immunosuppressant(-)-mycestericin E has been accomplished by using cinchona alkaloid-catalyzed asymmetric Baylis-Hillman reaction of an aldehyde with 1,1,1,3,3,3-hexafluoroisopropyl acrylate and Lewis acid-promoted cyclisation of an epoxytrichloroacetimidate as the key steps.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP2160896 1,1,1,3,3,3-Hexafluoroisopropyl acrylate 1,1,1,3,3,3-Hexafluoroisopropyl acrylate 2160-89-6 Price
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