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An Immunohistochemical Study of Keratin, Carcinoembryonic Antigen, Human Chorionic Gonadotropin and Alpha-Fetoprotein in Lung Cancer

An Immunohistochemical Study of Keratin, Carcinoembryonic Antigen, Human Chorionic Gonadotropin and Alpha-Fetoprotein in Lung Cancer

N Kimura, L Ghandur-Mnaymen

Tohoku J Exp Med. 1985 Jan;145(1):23-38.

PMID: 2580364

Abstract:

Immunohistochemical staining utilizing a peroxidase-antiperoxidase (PAP) technique for keratin, carcinoembryonic antigen (CEA), human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) was performed on paraffin sections from 72 cases of lung cancer obtained at autopsy. Positive reaction was shown in 44% of the cases for keratin, 77% for CEA, and 58% for HCG. AFP was positive in only one case of large cell carcinoma. Keratin was positive in 100% of squamous cell carcinoma, 53% of adenocarcinoma, 15% of small cell carcinoma and 45% of large cell carcinoma. CEA showed positive staining in 90% of squamous cell carcinoma, 88% of adenocarcinoma, 58% of small cell carcinoma and 69% of large cell carcinoma. CEA was the most useful tumor marker for detection of all types of lung cancer. HCG was positive in 30% of squamous cell carcinoma, 100% of adenocarcinoma, 23% of small cell carcinoma and 56% of large cell carcinoma.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414842	Carcinoembryonic Antigen human			Price

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