Home
Resources
Publications
An Overview of the Clinical Uses, Pharmacology, and Safety of Modafinil

An Overview of the Clinical Uses, Pharmacology, and Safety of Modafinil

Eric Murillo-Rodríguez, André Barciela Veras, Nuno Barbosa Rocha, Henning Budde, Sérgio Machado

ACS Chem Neurosci. 2018 Feb 21;9(2):151-158.

PMID: 29115823

Abstract:

Modafinil (MOD) is a wakefulness-inducing compound prescribed for treatment of excessive daytime sleepiness as a consequence of sleep disturbances such as shift work sleep disorder, obstructive sleep apnea, restless leg syndrome, or narcolepsy. While providing effective results in patients with sleepiness, MOD also produces positive outcomes in the management of fatigue associated with different conditions including depression, cancer, or tiredness in military personnel. Although there is clear evidence of the stimulant effects of MOD, current data also show that administration of this drug apparently induces positive neurobiological effects, such as improvement in memory. However, serious concerns have been raised since some reports have suggested MOD dependence. Taken together, these findings highlight the need to characterize the changes induced by MOD which have been observed in several neurobiological functions. Moreover, further work should follow up on the likely long-term effects of this drug if used for treatment of drowsiness and tiredness. Here, we review and summarize recent findings of the medical uses of MOD in the management of sleepiness and fatigue associated with depression or cancer as well as exhaustion in military personnel. We also discuss the available literature related with the cognitive enhancing properties of this stimulant, as well as what is known and unknown about MOD addiction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1726029	Modafinil Related Compound E		1726-02-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: