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An scFv Phage Clone That Binds to Human beta2-microglobulin

B Jwang, N Yerushalmi, R J Kreitman, J Engberg, I Pastan

Immunotechnology. 1999 Mar;4(3-4):231-6.

PMID: 10231092

Abstract:

Using phage display technology, a novel mouse scFv phage clone D1 was generated from mice immunized with single-chain HLA-A2, the human MHC class I molecules. D1 recognized a determinant in beta2-microglobulin. It reacted with beta2-microglobulin associated with the heavy chain of HLA-A2, recombinant beta2-microglobulin made in Escherichia coli or beta2-microglobulin prepared from human urine. The heavy chain variable region of D1 belongs to gene family VII and the light chain variable region belongs to the kappa chain gene family XI according to the Kabat database.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42414749 β2-Microglobulin from human urine β2-Microglobulin from human urine Price
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