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Analogues of the Neuroprotective Tripeptide Gly-Pro-Glu (GPE): Synthesis and Structure-Activity Relationships

Sergio A Alonso De Diego, Pilar Muñoz, Rosario González-Muñiz, Rosario Herranz, Mercedes Martín-Martínez, Edurne Cenarruzabeitia, Diana Frechilla, Joaquín Del Río, M Luisa Jimeno, M Teresa García-López

Bioorg Med Chem Lett. 2005 May 2;15(9):2279-83.

PMID: 15837309

Abstract:

A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP32302764 Gly-Pro-Glu Gly-Pro-Glu 32302-76-4 Price
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