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Analysis of Cinchona Alkaloids by High-Performance Liquid Chromatography. Application to the Analysis of Quinidine Gluconate and Quinidine Sulfate and Their Dosage Forms

Analysis of Cinchona Alkaloids by High-Performance Liquid Chromatography. Application to the Analysis of Quinidine Gluconate and Quinidine Sulfate and Their Dosage Forms

E Smith

J Chromatogr. 1984 Sep 7;299(1):233-44.

PMID: 6490780

Abstract:

The application of high-performance liquid chromatography to resolve the individual alkaloids present in marketed Cinchona alkaloids was investigated. Normal-phase and several reversed-phase systems were evaluated. The proposed procedure uses an alkylphenyl column; it adequately resolves quinidine, quinine, dihydroquinidine, dihydroquinine, cinchonine, cinchonidine, dihydrocinchonine and dihydrocinchonidine. Epiquinidine, epiquinine, quininone and quinitoxine are also resolved from quinidine and dihydroquinidine. This high degree of resolution enables the analysis of quinidine and its salts for their usual composition and establishes the absence of any cross-contamination or decomposition. The proposed procedure was applied to currently marketed samples of quinidine salts and their dosage forms. It was also applied to samples that were cross-contaminated or which contained decomposition products.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP485654	(+)-Dihydrocinchonine		485-65-4	Price

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