Home
Resources
Publications
Analysis of Drugs of Forensic Interest With Capillary Zone electrophoresis/time-of-flight Mass Spectrometry Based on the Use of Non-Volatile Buffers

Analysis of Drugs of Forensic Interest With Capillary Zone electrophoresis/time-of-flight Mass Spectrometry Based on the Use of Non-Volatile Buffers

Rossella Gottardo, Ivan Mikšík, Zeineb Aturki, Daniela Sorio, Catia Seri, Salvatore Fanali, Franco Tagliaro

Electrophoresis. 2012 Feb;33(4):599-606.

PMID: 22451052

Abstract:

The present work is aimed at investigating the influence of the background electrolyte composition and concentration on the separation efficiency and resolution and mass spectrometric detection of illicit drugs in a capillary zone electrophoresis-electrospray ionization-time of flight mass spectrometry (CZE-ESI-TOF MS) system. The effect of phosphate, borate and Tris buffers on the separation and mass spectrometry response of a mixture of 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, methadone, cocaine, morphine, codeine and 6-monoacetylmorphine was studied, in comparison with a reference ammonium formate separation buffer. Inorganic non-volatile borate and Tris buffers proved hardly suitable for capillary electrophoresis-mass spectrometry (CE-MS) analysis, but quite unexpectedly ammonium phosphate buffers showed good separation and ionization performances for all the analytes tested. Applications of this method to real samples of hair from drug addicts are also provided.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31041196	Codeine System Suitability Mixture			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: