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Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- To 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- To 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Iwona Jablonska, Wojciech Mielicki

Skin Pharmacol Physiol. 2019;32(3):125-131.

PMID: 30904911

Abstract:

Background/aims:
Analysis of the relationship between the estradiol blood concentration and the skin moisture, pore width, discoloration and smoothness in differently aged women on the 5th and 25th days of the menstrual cycle.
Methods:
The study involved 57 women divided into 4 age groups. Measurements of skin moisture, pore width, discoloration and smoothness were performed using the Aramo SG Aram Huvis device. The estradiol serum concentration was determined by radioimmunoassay.
Results:
In the luteal phase of the cycle, facial skin moisture increases from 93.5% of the correct standard moisture index in the youngest to 115.5% in the oldest group. A positive correlation (r2 = 0.45) between estradiol concentration and skin moisture was observed on the 5th day of the cycle in 40- to 50-year-olds. For women on the 25th day of the menstruation cycle, estrogen concentration below the normal range was more beneficial for skin smoothness and pore width for the oldest group. The difference was not statistically significant (p > 0.05); how-ever, in the 40- to 50-year age group, skin smoothness was much better (43.5 ± 6.7%) for low estradiol while it was 37.5 ± 4.7% in the 20- to 29-year age group. Similarly, in the 40- to 50-year age group, skin pore width was much smaller (35.2 ± 15.7%) for low estradiol while it was 54.3 ± 28.8% in the 20- to 29-year age group.
Conclusions:
Skin moisture was related to the concentration of estradiol only in the oldest examined group of women regardless of the phase of menstrual cycle. In the 40- to 50-year-old group of women, the low level of estradiol on the 25th day of the cycle is better used to maintain a good facial skin appearance and has a positive influence not only on skin moisture, but also on pore width and skin smoothness.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS2121438	Human serum (17β-estradiol, low level)			Price

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