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Anionic Oligothiophenes Compete for Binding of X-34 but Not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ

Anionic Oligothiophenes Compete for Binding of X-34 but Not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ

Marcus Bäck, Hanna Appelqvist, Harry LeVine 3rd, K Peter R Nilsson

Chemistry. 2016 Dec 19;22(51):18335-18338.

PMID: 27767229

Abstract:

Deposits comprised of amyloid-β (Aβ) are one of the pathological hallmarks of Alzheimer's disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X-34, a Congo Red analogue, but not Pittsburgh compound B (PIB) from recombinant Aβ amyloid fibrils and Alzheimer's disease brain-derived Aβ. Overall, we foresee that the oligothiophene scaffold offers the possibility to develop novel high-affinity ligands for Aβ pathology only found in human AD brain, targeting a different site than PIB.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP215294987	X-34		215294-98-7	Price

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