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Antagonism of the 5-HT-induced Bronchoconstriction in the Cat

Antagonism of the 5-HT-induced Bronchoconstriction in the Cat

R Reiche, H H Frey

Arch Int Pharmacodyn Ther. 1983 May;263(1):139-45.

PMID: 6615080

Abstract:

In cats in which bronchoconstriction was induced and maintained by infusion of 5-HT, the bronchodilator effects of ketanserin, a related compound, cyproheptadine, clenbuterol and aminophylline were compared. The novel 5-HT2 antagonists ketanserin and R50970 were active in doses of about 10 nmol/kg, cyproheptadine was about 5 times less potent, but had a longer duration of action. Clenbuterol and aminophylline were only partially effective against 5-HT-induced bronchoconstriction. There was no reliable effect of the 5-HT antagonists against carbachol-induced bronchoconstriction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP256815	Cyproheptadine Related Compound A		256-81-5	Price

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