Home
Resources
Publications
Antagonist of Neuronal Store-Operated Calcium Entry Exerts Beneficial Effects in Neurons Expressing PSEN1ΔE9 Mutant Linked to Familial Alzheimer Disease

Antagonist of Neuronal Store-Operated Calcium Entry Exerts Beneficial Effects in Neurons Expressing PSEN1ΔE9 Mutant Linked to Familial Alzheimer Disease

Daria Chernyuk, Nikita Zernov, Marina Kabirova, Ilya Bezprozvanny, Elena Popugaeva

Neuroscience. 2019 Jul 1;410:118-127.

PMID: 31055008

Abstract:

Alzheimer's disease (AD) is the neurodegenerative disorder with no cure. Recent studies suggest that dysregulated postsynaptic store-operated calcium entry (nSOCE) may underlie mushroom spine loss that is related to AD pathology. In the present study we observed that PSEN1ΔE9 familial AD (FAD) mutation causes mushroom spine loss in hippocampal neuronal cultures. We also demonstrated that amplitude of TRPC6-mediated nSOCE is increased in PSEN1ΔE9-expressing neurons and we suggested that inhibition of nSOCE may help to rescue synaptic defects in this model. We further established that nSOCE antagonist EVP4593 decreases PSEN1ΔE9-mediated nSOCE upregulation and rescues mushroom spines in PSEN1ΔE9-expressing neurons. Obtained results further highlight the connection between dysregulation of endoplasmic reticulum calcium signaling and synaptic loss in AD and suggest that calcium signaling modulators may have a therapeutic value for treatment of memory loss in AD.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP545380345	EVP4593		545380-34-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: