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anti-1-Amino-3-[ 18 F]fluorocyclobutane-1-carboxylic acid

anti-1-Amino-3-[ 18 F]fluorocyclobutane-1-carboxylic acid

Kam Leung

PMID: 20641517

Abstract:

A variety of 11C- and 18F-labeled amino acids have been studied for potential use in positron emission tomography (PET) oncology (1, 2). Most brain tumors show an increased uptake of amino acids as compared with normal brain (3). These amino acids are composed of naturally occurring amino acids, such as, l-[11C]leucine, l-[11C]methionine, and l-[11C]tyrosine, and non-natural amino acids, such as [11C]aminoisobutyric acid, [11C]1-aminocyclopentane-1-carboxylic acid, and [11C]1-aminocyclobutane-1-carboxylic acid. There are also 123I-labeled amino acids used in imaging in oncology (4-6).The natural amino acids are taken up by tumor cells through an energy-independent L-type amino acid transporter system and retained in tumor cells because of their higher metabolic pathways, including incorporation into proteins than most normal cells (4). l-[11C]Methionine and [18F]fluorotyrosine have been widely used in the detection of tumors. On the other hand, the non-natural amino acids are not metabolized. Their uptakes are through both the L-type transporter and the energy-dependent A-type transporter (7). Therefore, they can be accumulated intracellularly in high concentrations. anti-1-Amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-[18F]FACBC) was shown to have a high tumor/brain ratio (8). Therefore, anti-[18F]FACBC could be a useful tracer in PET tumor imaging.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP41365757	1-Amino-3,3-diethoxypropane		41365-75-7	Price

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