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Anti-allergic Effects of His-Ala-Gln Tripeptide in Vitro and in Vivo

Mamoru Tanaka, Hiroyuki Watanabe, Yoshinobu Yoshimoto, Hana Kozai, Takeaki Okamoto

Biosci Biotechnol Biochem. 2017 Feb;81(2):380-383.

PMID: 27728999

Abstract:

We examined the inhibitory effects of HAQ (His-Ala-Gln) peptide on type-1 allergy in vitro and in vivo. HAQ peptide inhibited β-hexosaminidase release and intracellular Ca2+ levels of rat basophilic leukemia RBL-2H3 cells. Oral administration of a HAQ peptide-added diet (1 mg/mouse/administration) to C3H/HeJ mice for 14 days led to significant suppression of allergic symptoms, but did not reduce allergen-specific IgE or IgG1.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP39537230-B Ala-Gln Ala-Gln 39537-23-0 Price
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