Home
Resources
Publications
Anti-angiogenic Effect of Chebulagic Acid Involves Inhibition of the VEGFR2- And GSK-3β-dependent Signaling Pathways

Anti-angiogenic Effect of Chebulagic Acid Involves Inhibition of the VEGFR2- And GSK-3β-dependent Signaling Pathways

A P Athira, C S Abhinand, K Saja, A Helen, P Reddanna, P R Sudhakaran

Biochem Cell Biol. 2017 Oct;95(5):563-570.

PMID: 28467858

Abstract:

Inhibition of angiogenesis is a useful strategy to prevent cancer growth by targeting new vessels that grow to nourish actively proliferating tumor cells. Endothelial cells can use a number of different pathways to cause angiogenesis, and each step in these pathways can be targeted. The use of multi-targeted drugs is gaining much importance in this scenario. Our previous results have shown that chebulagic acid (a benzopyran tannin present in the fruits of Terminalia chebula) has anti-angiogenic properties. Thus, this study was designed to examine the molecular mechanism for the anti-angiogenic effects of chebulagic acid. Results from our investigations using molecular docking studies and human umbilical vein endothelial cells in culture suggested that chebulagic acid inhibits both GSK-3β-dependent β-catenin phosphorylation (an important mediator of VE-cadherin-β-catenin signaling) and VEGFR2 phosphorylation, which is an important step in VEGF signaling. Chebulagic acid inhibits angiogenesis by blocking both the VEGF-VEGFR2 complex and cell-cell contact dependent downstream signaling pathways.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23094715	Chebulagic acid		23094-71-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: